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19/10/2019
Home Page > Vice Chancelleries > Vice Chancellery for Research & Technology > Research Centers > Molecular Medicine Research Center > MMRC research projects 
Research projects of Molecular Medicine Research Research Center (MMRC)
1-Survey the cytotoxic and anticancer effects of Silybum marianum by determination the expression level of Nanog, Oct4 and p53 genes in colon cancer cell line (HCT116).
2-Investigation of the expression pattern of five effective miRNAs in neuronal development in mild retarded patients in Rafsanjan city.
3-Study of frequency and type of Y chromosome microdelitions in infertile men referring to the Urology Clinic of Moradi Hospital in Rafsanjan city compared to fertile men. A case-control study.
4-Skin tissue engineering of ِcamel small intestinal layer and rat mesenchymal stem cell to investigate animal skin wound healing model.
5-Effect of oxytocin and α-tocopherol on differentiation of human adipose derived stem cells (hADSCs) into cardiomyocytes in the three dimensional fibrin scaffold.
6-The effect of eight weeks different exercise of training (endurance, strengh and combined) with the vitamin D on glutathione peroxidase activity, indexes of oxidative stress and muscle damage in male rats with fructose-induced metabolic syndrome.
7-The study of gene expression profile of BCL2 gene family in tumor cell lines (AGS, 5637 and U87MG) after OCT4B1 suppression.
8-The Effect of cold atmospheric plasma on the expression of Apoptosise genes in breast cancer cell line (MCF-7)
9-Evaluation of the expression pattern of some chemokines and their receptors in the peripheral blood mononuclear cells from Helicobacter pylori-infected peptic ulcer patients following stimulation with crude antigens and influence of the ginger hydroalcoholic extract on their expression.
10-Comparison of the effect of general and spinal anesthesia on serum levels and gene expression of interleukins 4, 6, 10, 17, TGF-β and IFN-γ in maternal and umbelical cord blood in elective cesarean section.
11-the effects of OCT4B1 variant suppression on gene expression profile of small heat scock gene familly (small HSPs) in AGS (adenocarcinoma), 5637 (bladder carcinoma) and U87MG (brain tumor) Cell Lines.
12-The Anti-cancer effects of a vanadium (IV) metal complex on Hepato cell carcinoma (HepG2) cell line and its effects on the expression of a number of apoptotic pathway genes and study of the intraction of this compound with salmon sperm DNA and bovine serum albumin (BSA).
13-Comparative study of the effect of albendazol and its metal complexes on protoscolex of Echinococcus granulosus at in vitro condition and preparation of nanofibers from the effective formulation of the drug.
14-Investigating the impact of paternal nicotine exposure on offspring high-fat diet induced obesity, and the pathological response of the liver and pancreas using C57BL/6 mouse model.
15-The survay of expressional profiles of some effective micro RNA in MCF7 cancer cell line, cancer and normal tissue of breast cancer patients referred to the , Ali ibn Abi Talib hospital city of Rafsanjan.
16-The effect of estrogen treated mesenchymal stem cells supernatant on the clinical symptoms and the expression of some genes involved in the immune responses in rats with experimental autoimmune encephalomyelitis.
17-Comparison of therapeutic effects of lipid tissue derived mesenchymal stem cells (MSCs) with sulfasalazine in the animal model of ulcerative colitis.
18- The study of cell cycle gene expression profile following OCT4B1 suppresion in gastric Tumor Cell Lines(AGS).
19-Evaluation of expression of some epigenetic-related genes (DNMT and HDAC1) in patients with lupus and rheumatoid arthritis referring to Rafsanjan Rheumatology Clinic in 2017.
20-The effect of liposomal form of an indole deravative on the expression of Bcl-2, BAX, PML/RARα ,P21 genes in NB4 cell line.
21-Study of therapeutic effects of Platelet Rich Plasma (PRP) on the animal model of inflammatory bowel disease (IBD).
22-Study of the effect of vaccination with Toxoplasma gondii encapsulated into liposome nanoparticles on the serum levels of cytokines IL-12, IL-17 and IL-10 in the mice.
23-Evaluation of the effects of a novel indolic compound on the expression of immortalization gene (SALL4) and PML/RARα fusion gene in acute promylocytic leukemia cell line NB4.
24-Evaluation of the effects of a novel indolic compound on the expression of immortalization gene (SALL4) and PML/RARα fusion gene in acute promylocytic leukemia cell line NB4.
25-the effects of Pistacia phenolic compound on the expression of some apoptosis pathway genes in breast cancer cell line (MCF-7(
26-The study of OCT4B1suppression effects in expressional profile of microRNAs in U87-MG cell line(malignant brain tumor).
27-Suppression of HMGA2 gene expression by small interference RNA (siRNA) and evaluation of their apoptotic induction effect in Acute myeloid leukemia cell line (KG1).
28-Assessment of the inhibitory effects of different doses of synthetic fluoroquinolone derivatives on the activity & expression of DNA gyrase of some gram positive and negative bacteria
29-Investigation of the anti-apoptotic gene family gene expression profile, following the inhibition of the OCT4B1 variant in the three AGS 5637 and U87MG cancer cell lines.
30-Eight interactive effects of different exercise training (endurance, strength and combination) with of vitamin D on body weight, visceral fat and food intake in rats with metabolic syndrome induced by fructose.
31-Survey the effects of Pistacia fruit phenolic compound on the expression of some apoptosis pathway genes in breast cancer cell line (MCF-7).
32-Effect of oxytocin and α-tocopherol on differentiation of human adipose derived stem cells (hADSCs) into cardiomyocytes in the three dimensional fibrin scaffold.
33-Evaluation of(2R,4S)-N- Aryl-4-hydroxy-1 -(2,2,2 trifluoroacetyl)pyrrolidine-2-carboxamide 's effect on viability and Apoptosis in HepG2 and SW1088 cancer cell lines by MTT and Annexin-V assay.
34-Effect of saffron extract on survival and apoptosis of AGS cancer cell line by MTT and Annexin-V.
35-Comparison of some biochemical and inflammatory factors, serum levels of exposed individuals in Sarcheshmeh copper industrial pollution in Rafsanjan compared to controls.
36-Evaluation of oxidative stress and serum chemerin adipokine levels in patients with metabolic syndrome and healthy subjects.
37-Evaluation of the C5a and C3a prior and post chemotherapy in patients suffering from acute myeloid leukemia.
38-A survey on the effect of prosopis farcta seeds hydroalcholic extract on metabolic syndrome in male rat.
39-Evaluation of the effect of albendazole encapsulated in dense lipid nanoparticles on hydatid cyst by intravenous method.
40-Study the effect of extremely-low frequency magnetic fields on induction of sleepiness in male mice; base on behavioral patterns and biochemical factors.
41-The effect of carotenoid Crocin on serum level and expression of BDNF-derived brain neurotrophic factor gene expression and expression of CREB binding protein element in the abdominal tagamental region after morphine dependence in maintenance condition Methadone in male rats.
42-The effect of Iranian hydrochloric hydroalcoholic extract on the expression of some genes involved in epigenetics in liver Hep_G2 tuberculosis.
43-Effect of hydroalcoholic extract of Cornus mas on the expression of genes of the mitochondrial pathway of apoptosis in AGS cancer cell line (gastric adenocarcinoma).
44-The effect of nyzine peptide on survival and apoptosis of HepG2, MCF-7 and SW1088 cancer cells by MTT and Annexin-V.
45-The effect of secreted mesenchymal secretion of mesenchymal stem cells with 17 beta-estradiol on the clinical and serum levels of 8 and 9 NOx metalloproteinase matrix proteins in experimental encephalomyelitis in male rats.
46-Evaluation of the serum levels of CCL17 chemokine and their receptor (CCR4) in peripheral blood from patients with acute lymphoblastic leukemia (ALL).
47-Evaluation of anticancer activity of capparis extract on the survival of MCF7 breast cancer cell line and on expression of MIR-21 and MIR-17-5p.
48-Evaluation of anti-Toxoplasma effects of combining herbs of Artemisia annua, Glycyrrhiza glabra, Sophora flavescens and Ginkgo biloba in Mouse Model.
49-Exraction of Gold NanoParticles from Walnut Green Shell and Survey the cytotoxic and anticancer effects in breast cancer cell line (MCF7).
50-Investigation of the Pattern of Some Micro RNAs in Rheumatoid Arthritis Patients Referring to Rheumatology Clinic of Rafsanjan in 2019.
51-Investigation of Heme Oxygenase- 1(HO-1) gene expression pattern in different cancer cell lines.
52-Evaluation of IgG avidity against Toxoplasma secretion antigens for the detection of Toxoplasmosis
Determination of serum and hematopoietic levels of chemokine in GRO, MIG, IP-10, SDF1 in patients with cutaneous leishmaniasis.
53-Comparison of IL-4 gene polymorphism with serum IL-4 production and serum immunoglobulin E levels in Helicobacter pylori infected peptic ulcer patients and healthy subjects.
54-Effect of Persian Ginger extract on glycosylation of albumin in exogenous state
Studies on the effects of Walnut leaves on the level of a number of blood biochemical factors in diabetic male rats.
55-Study of the Levels of GRO, MIG, IP-10, SDF1 Chemokines in Adult T Cell Leukemia Patients Compared to HTLV-1 Blind Species .
56-Prevalence of hepatitis G in blood recipients in Kerman province. 
57- Investigation of Corber Fruit Extract. Histological changes in type 1 and healthy male diabetic rats. 
58- Evaluation of PTEN gene mutation and evaluation of its importance in the progression and prediction of esophageal carcinoma carcinoma. 
59- Investigation of allium hirtifolium mucus extract on the level of edinuponkin and the extent of expression of apmin1 of edinuponkin in adipose tissue and insulin resistance status in type 2 diabetic rats (induced with streptozotocin and nicotinamide) and normal.
60- Investigation of allium hirtifolium mucus extract on the level of edinoponkin and the extent of expression of apm1 edinuponkin gene in adipose tissue and insulin resistance status in type 2 diabetic rats (induced with high fat and fructose diet) and normal.
61- Evaluation of the relationship between HCV -circular hepatitis (HCV) and the course of disease and HBV infection in patients with chronic blood transfusions in Kerman province using Real Time-PCR..
62- Evaluation of serum level of CC chemokines in patients with breast cancer before and after chemotherapy.
63- Evaluation of protein levels of mRNA and EOTAXIN, MCP-1, RANTES chemokines in patients with gastrointestinal cancer before and after chemotherapy 
64- Evaluation of serum level and expression of CCL2, CCL5 in patients with transcranial cell carcinoma of the bladder (TCC) at the level of mRNA and protein. 
65- Evaluation of serum level and expression of CCL24, CCL CCL26 in patients with transcranial cell carcinoma of the bladder (TCC) at the level of mRNA and protein. 
66- Determination of the Excretion-Secretion Antigens of Toxoplasma from the Maintenance of Toxoplasma gondii tachyzoites in non-cellular and peritoneal cell media
67- Comparative study of the expression profile of some of the main genes controlling self renewal pathway in pathological samples of patients with bladder cancer and 5637 cell line and (HT1376 bladder tumor). 
68- Effect of Allium hirtifolium extract on the formation of hemoglobin glycated acetic acid and AGEPS in extubation. 
69- Investigation of the inflammation ratio to active and inactive forms of Toxoplasma gondii in blood donors of Rafsanjan Blood Transfusion Organization using ELISA, Real-Time 
70- Frequency of Trichomonas vaginalis infection in symptomatic pregnant women referring to Niknafs teaching hospitals in Rafsanjan by using culture and PCR method in the year 91.
71- Surveying the serum level of CXC chemokines in patients with alopecia areata. 
72- Effects of white berry leaves extract on key enzymes of glucose metabolism pathways in liver cells in type 1 and normal diabetic rats. 
73-The study of the effect of bitter almond on the expression of some apoptosis route pathogens (planned death), in breast cancer cell line (MCF-7) by PCR Arry method. 
74- Determination of serum chemokine Eotoxin1 in patients with cutaneous leishmaniasis.
75- Evaluation of the Effect of Sesame Diet on Primary Dysmenorrhea in Female Students of 18- 25 Years of Rafsanjan University of Medical Sciences. 
76- Comparison of Survivian Expression Patterns (IAP) in Bladder Cancer Biopsy Samples of Cancer Cell Line 5637 and Normal Tissue. 
77- The effect of wild pistachio powder on a number of blood biochemical metabolites in hyperlipidemic patients.
78- Evaluation of the expression profile of BAK1, BAX, BCL2, CIDEA, CASP1 and TNFRSF1A genes (apoptosis pathway genes) following the control of OCT4B1 variant in three AGS '5637 and U87MG cancer cell lines.
79- Evaluation of serum levels of CXCL1 and CXCL10 and CXCL12 in patients with leukemia receiving bone marrow transplantation before and after transplantation. 
80- Effect of Allium hirtifolium extract on albumin glycosylation. 
81- Evaluation of the effect of 2- (1 - ((2,4-Aryl) imino) -2,2,2-trifluoroethyl) -1H indole-3-carbaldehyde on different genes of apoptosis, immortality and cell cycle in NB4 cell line acute leukemia. 
82- The Effect of Hydroalcoholic Extract of Citrullus Colocynthis on Blood Glucose Reaction in Heterogeneous Environment. 
83- The effect of nyzine peptide on the expression profile of apoptotic pathway genes in HepG2, MCF-7 and AGS cancer cells by PCR array technique. 
84- Evaluation of the effect of orlistat on the expression of Octamer 4 (OCT4), NANOG, SRY-related HMG-box gene 2 (SOX2), LIN28 and Krupel-like factor 4 (KLF4) genes in colorectal cancer cells.
85- Determination of the effect of resveratrol on growth of breast cancer cells and the expression of APOBEC3B, TET and DNMT genes. 
86- Evaluation of the therapeutic effect of albendazole encapsulated in densely lipid nanoparticles on hydatid cyst by intravenous method.
87- Evaluation of Pneuroxin 3 in Coronary Artery Disease Patients in Comparison with Protein and Gene Levels. 
88- Evaluation of the effect of aqueous-alcoholic extract of ridge on some biochemical parameters in rat with metabolic syndrome. 
89- Evaluation of the separate and combined effects of metformin, ibuprofen and cimetidine on T-helper type 1 (TH1) and T-regulating (Treg) cells in an animal model of breast cancer.
90- Investigation of the effect of pyrolidine-2-carboxamide anticancer compounds on the expression profile of apoptosis pathway genes in HepG2 cell line by PCR array technique .
91- The effect of Iranian hydrochloric hydroalcoholic extract on the expression of some genes involved in epigenetics in Hep_G2 tuberculosis of liver cancer .
92- The effect of Cornus mask hydro alcoholic extract on the expression of mitochondrial pathway genes in apoptosis in AGS (gastric adenocarcinoma) .
93- Effect of apoptosis on N- (1-3- (di (1H-tetrazol-5-yl) methyl) -1H-indol-2-yl) -2,2,2-trifluoroethyl) anilin (IC50) on cancer cells of the liver HpeG2. 
94- Comparison of some biochemical and inflammatory factors, serum of people exposed to industrial pollution in Sarcheshmeh Rafsanjan copper in comparison with control subjects. 
95- The effect of saffron extract on survival and apoptosis of AGS cell line by MTT and Annexin-V 
96- Investigating the inhibitory effects of different doses of synthetic derivatives of fluoroquinolones on the activity of DNA gyrase enzyme in RNA level of some gram positive and gram negative bacteria .
97- Investigation of neurotrophic effect of orexin-A on neuronal damage caused by high sugar in vitro and in vitro conditions.
98- Evaluation of Methadone Effect on Global Methylation and Apoptosis in Nervous Cells, Astrocytes 
99- The effect of secreted mesenchymal secretion of mesenchymal stem cells treated with 17 beta-estradiol or without treatment on the clinical presentation and the expression of the metalloproteinase 8 and 9 matrix genes and the enzyme NADPH Oxidase (NOx in the experimental model of multiple sclerosis. 
100- Effect of Naringin on inflammation, oxidative stress and tissue damage after regular exercise in male rats. 
101- Effect of hydroalcoholic extract and phenolic compounds of leaf and pistachio fruit (Pistacia atlantica) on induction of apoptosis in breast cancer cell lines (mcf-7), liver (Hep G2) and colorectal (SW742). 
102- Effect of Fenugreek Hydroalcoholic Extract on Some Biochemical Factors and Oxidative Stress Levels in Male Rats with Metabolic Syndrome. 
103- Investigating the Effect of N-Aryl 4-Hydroxy-1- (2, 2, and 2-Trifluoro Steyl) Pyrrolidine-2-Carboxamides on the Survival Rate and Apoptosis of HepG2 and V SW1088 Cancer Cells by MTT and Annexin-V. 
دانشگاه علوم پزشکی رفسنجان
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