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  • Research Projects Approved at the Center

 Research Projects Approved at the Center from 2012 to date

 

Row

Title of the project

Approved Year

1

The comparisoin of expression rate of the IRF7 pathway molecules in immune cells of active chronic HBV infected patients in to healthy control

2012

 

2

Evaluation of the expression rate of NLRP1, NLRP3 and NLRC4 in immune cells of active chronic HBV infected patients.

3

Evaluation of the expression rate of RIG1 and MDA5 in immune cells of active chronic HBV infected patients.

4

Evaluation of Immunological Status Against Tetanus Among the Rafsanjan University of Medical Science`s Students in 2012.

5

Comparison of antibacterial effects ofCamellia sinensisebrewed and aqueous extract on some gram positive and gram negetive bacteria: An in vitro study

2013

6

Evaluation of the miRNA-155 effects on the family of TNF molecules of programmed cell death in jurkat lymphocyte cell line using PCR Array technique

7

Examination of association of cord blood and maternal serum level of IL-17 and TGFβ with kind of birth (Preterm and on time)

8

Evaluation of the effect of pistachio hull extract and its purified ingredient on the TNF, TRAF, BCL2 and IAP families using PCR Array technique

9

Evaluation of the miRNA-155 effects on the family of CARD domain-containing molecules of programmed cell death pathways in jurkat cell line using PCR Array technique

10

Effect of nisin on virulence genes expression ofStaphylococcus aureus

2014

11

Effect ofLactobacillusstrains culture supernatants on virulence genes expression ofStaphylococcus aureus

12

Prevalence of Chlamydial and  Neisserial infections  in infertile men using Polymerase Chain Reaction(PCR) in Rafsanjan- 2014

13

Evaluation of serum levels of IL6, IL 8 and TNF-α in the term and posterm neonates and their mothers according to the various ranges of depression and anxiety

2015

14

Evaluation of the expression levels of RIP1 and IPS-1 in immune cells of chronic HBV infected patients and their relation with serum levels of liver enzymes and various status of HBeAg and HBV-DNA

15

Evaluation of serum levels of IL-6, IL-8, TNF-α and TGF-β in the chronic hepatitis B infected patients with various range of depression and anxiety

16

Comparison of serum levels of IgE, IL-6, IL-8, TNF-α and TGF-β in the epitaxis patients and healthy control

17

The Study Microbial quality of pistachio at different terminals of pistachio processing

2016

18

A study on the effect of latent infection ofToxoplasma gondiion tactile learning in male rats

19

Evaluation of the Alone or in combination with each other effects of metformin, ibuprofen, and cimetidine on the expression of specific transcription factors of TH1(T-bet) and TH2 (GATA3) cells in an animal model of breast cancer   

20

The comparison of serum levels of IL-4, IL-10, IFN-γ, IL-17A, and IL-23 in the epistaxis patients and healthy controls 

2017

21

A Novel Size-Specific-Dose-Estimate-Based (SSDE-Based) Method for Patient Dose Optimization in Iranian adults Chest, Abdomen and Pelvis CT examinations in Rafsanjan during 2017  

22

Serum level detection of IL-6, TNF-α and TGF-β and its correlation with the severity of the disease in COPD patients referred to Rafsanjan Ali-ibn Abi Talib hospital 

23

Evaluation of serum levels of interleukin 4 and Delta 32 mutation in the CCR5 gene in patients under coroner arteries angiography

2018

24

The frequency of antibiotic-associated diarrhea due to Clostridium difficile in hospitalized patients at Internal Medicine Ward and ICU of Rafsanjan Hospital of Ali-Ebne- Abitaleb

25

Evaluation of immunoregulatory effects of royal jelly of the honey bee and silver-nanoparticle on the liver and kidney levels of IL-1β, IL-2, IL-6 and IL-33 in the Male Rat

26

Evaluation of the effects of coronary artery angiography on the serum levels of interleukin 1β and interleukin 2        

27

Investigating the effect of phytosomal curcumin on the expression of some inflammatory and anti-inflammatory genes an animal model of rheumatoid arthritis

28

Evaluation of immunoregulatory effects of royal jelly of the honey bee and silver-nanoparticle on the liver and kidney levels of IL-1β, IL-2, IL-6 and IL-33 in the Male Rat

 

2019

29

Evaluation of the immunomodulatory effects of mesenchymal stem cell therapy and royal jelly on the expression of various T lymphocyte clone transcription factors in the model of middle cerebral artery occlusion in mice

30

Survey on the serum levels of IFN-g of maternal and umbilical cord blood in term and post-term delivery

31

Preparation of a nano-scale formulation from the antibacterial drug trimetoprim using magnetic nanoparticles modified by silver nanoparticles

32

The efficacy of dendritic cell vaccine in inhibiting tumor angiogenesis and metastasis and inducing apoptosis in mice with breast cancer receiving of apelin receptor antagonist

33

Investigating the effect of ginger extract and sweet almond oil on the tolerance of enteral feeding and the incidence of ventilator-associated pneumonia in patients hospitalized in the special care department of Ali Ibn Abitaleb Hospital in 2018

34

The effect of ginger and sweet almond oil on enteral Nutrition tolerance and incidence of ventilator-associated pneumonia (VAP) in patient’s hospitalized in the Intensive Care Units of Ali Ebn Abitaleb hospital in Rafsanjan-2019

35

Determination of the serum IL-25&17  levels in patients with or without osteoarthritis referring to Rafsanjan’s Rheumatology clinic in year 2020

36

Evaluation of antibiotic resistance among clinical isolates of  Pseudomonas aeruginosa and comparison of inhibitory effect of Gallium with antibiotics in the laboratory  condition

37

Evaluation of local and systematic using of nanoemulsion of Honey Bee venom on the inflammation and serum levels of endothelin-1 in rat arthritis rheumatoid model

38

Effects of conditioned medium (CM) and extracts of breast cancer cells lines MCF-7 and MDA-MB-231 on adipose-derived mesenchymal stem cell

39

Frequency of viraemia in patient with Covid-19 disease

2020

40

Prevalence of Clostridium difficile and its relation to tissue level of IFN-γ and IL-4 cytokines in acute appanecitis patients

41

Comparison of clinical, paraclinical And demographic factors among suspected COVID19 patients and PCR positive patients referred to Ali Ibn Abi Talib Medical Training Center of Rafsanjan University of Medical Sciences in 2020.

42

Evaluation of relation between serum levels of interleukin-2 and 8 with microRNA-155 in the patients infected with COVID-19

43

Evaluation of serum levels of IL-4 and IFN-γ and microRNA-155 in the patients infected with Cov-sars2 and healthy controls

44

Investigating the effect of polymeric nanostructures containing royal jelly on TH17 and regulatory T cells' parameter in PBMC of rheumatoid arthritis patients

45

Investigating the changes in the iron metabolism-related factors (ferritin, transferrin, TIBC) in patients with COVID-19

46

Investigation of the frequency of Metabolic Syndrome and affected factors in its incidence in Rheumatoid Arthritis Patients Referring to Rheumatology Clinic of Rafsanjan and control group in 2020

47

Investigation of the frequency of Metabolic Syndrome and affected factors in its incidence in Osteoporosis Patients referring to rheumatology clinic of Rafsanjan and control group in 2020

48

A study on the Inhibitory effects of Tribulus terrestris extract on growth and biofilm formation of some cariogenic bacteria: an in vitro study

49

Evaluation of CCL2 / CCR2 axis expression in different groups of patients with COVID-19 in Rafsanjan

2021

50

Evaluation of expression of some molecules involved in TGF-β / TGF-βR and IFN-I / IFNAR axes in patients of different ages with COVID-19 in Rafsanjan

51

Evaluation of expression levels of S100A4, S100A9 and S100A10 gene in the patients infected with COVID-19

52

Evaluation and comparison of expression levels of some toll like receptors in the epithelial cells of respiratory tract in the patients infected with Cov-sars2 with various statuses of clinical symptoms and healthy controls

53

Evaluation of the expression of toll like receptor 3, 7, 8 and 9 in the epithelial cells of the upper respiratory tract in the patients infected with Cov-sars2 compared with healthy individuals

54

Assessment of the mRNA levels of inflammasomes, ASC and caspase 1 in the patients infected with Cov-sars2 with various rages of clinical symptoms and healthy controls

55

Evaluation of the relationship between inflammasome activation pathway and neutralizing antibody levels in response to COVID-19-vaccine (Oxford–AstraZeneca

56

Evaluation of the relationship between the gene expression of Intracellular nucleic acid sensors and the level of neutralizing antibodies in response to COVID-19-vaccine (Oxford–AstraZeneca)

57

Evaluation of the relationship between improvement or induction of allergic diseases after treatment with classical and biological Disease-modifying ant rheumatic drugs (DMARD) in referred patients with rheumatoid arthritis to Rheumatology clinic in Rafsanjan city

58

Evaluation of the effects of either first or second injections of the COVID-19-vaccine (Oxford–AstraZeneca) on the serum levels of CCL2, CCL3 and IL-29

59

Evaluation of the serum levels of dehydroepiandrosterone sulfat (DHEA-s) and its potential effect on the quality and quantity of the immune responses as well as severity of unwanted symptoms following administration of COVID-19 vaccine (Oxford–AstraZeneca)

60

Evaluation of the serum levels of Trace elements (Selenium, Magnesum, and Zinc) and their effects on immune system responses as well as severity of symptoms following administration of COVID-19 vaccine (Sinopharm)

61

Evaluation of the expression levels of Caspase 3, 8 and 9 in the respiratory epithelial cells and serum of the patients infected with COVID-19 (Corona) with various clinical symptoms

62

Fabrication and evaluation of silica mesoporous nanoparticles containing Doxorubicin and Apigenin on induction of apoptosis and inhibition of invasion in MDA-MB-231 breast cancer cells

2022

63

Nafcillin loading into liposome nanoparticles to increase its antibacterial effect against infection of methicillin-sensitive staphylococcus aureus: an in vitro study

64

Evaluation the anticancer effect of PEGylated niosome nanoparticles in the treatment of breast cancer in an animal model of Balb/C mice

65

Evaluation of expression levels of toll like receptors in the peripheral blood cells of the patients with osteoporosis referred to the densitometry center of Rafsanjan in 2022- 2023

66

The effect of opium on clinical symptoms and laboratory tests of referred patients with rheumatoid arthritis to Rheumatology clinic in Rafsanjan city

67

Prevalence of blood group types in patients with knee osteoarthritis referred to rheumatology clinic of Rafsanjan in 2022

68

a survey on the frequency of non-alcoholic fatty liver disease and some factors affecting it in patients with lupus in who has referred to rheumatology clinic of Rafsanjan university of medical sciences in 2022

69

Antimicrobial effects investigation of silver nanoparticles attached to respiratory tracheal tube

70

Evaluation of cytokine profile (Th1 / Th17) and risk of infection with SARS-CoV-2 in Rheumatoid Arthritis Patients treated with biologic DMARD Referring to Rheumatology Clinic of Rafsanjan

71

Evaluation of DNA methylation in signaling pathways of DNA repair and cell cycle in Locally advanced prostate cancer patients pre-and post-radiotherapy

72

Effect of lavender oil on some clinical symptoms of patients with knee osteoarthritis referred to the rheumatology clinic of Ali Ibn Abi Talib Hospital in Rafsanjan in 2022: a double blind randomized control trial

73

The Prevalence of renal manifestations and some related factors in Lupus patients referred to Rafsanjan Rheumatology Clinic from 2019 to 2022

74

Evaluation of monocyte, neutrophile and platelet to lymphocyte ratio in osteoporosis and osteopenic patients with healthy individuals referred to the densitometry center of Rafsanjan city: A case-control study

75

Prevalence of blood group types in patients with osteoporosis referred to the densitometry center of Rafsanjan in 2023

 

 

 

 

 

 

 

2023

76

Prevalence of blood group types in patients with osteoporosis referred to the densitometry center of Rafsanjan in 2023

77

Evaluation of gene expression of immune checkpoint molecules in rheumatoid arthritis patients with and without covid 19 (corona) treated with DMARD referring to Rafsanjan rheumatology clinic

78

Investigation the effect of achillea millefolium oral supplement on some biochemical and inflammatory blood factors in patients with type 2 diabetes referred to Rafsanjan diabetes clinic, in 2023

79

Survey of antibiotic resistance of Acinetobacter baumannii isolated from out- and in- patients of Ali Ebne Abi Taleb Hospital, Rafsanjan city during 2022-2023

80

Investigation of the frequency of metabolic syndrome and its components in gout patients referred to the rheumatology clinic of Rafsanjan city compared to healthy individuals in 2023

81

Investigation the ratio of monocytes, neutrophils and platelets to blood lymphocytes in patients with systemic lupus erythematosus referred to the rheumatology clinic of Rafsanjan compared to healthy people in 2023

82

Determining the effect of crocin on some of inflammatory cytokines and genes involved in asthma and oxidative stress in wistar rats with ovalbumin-induced asthma.

83

Synthesis and evaluation of Anti-Scar Nanofibrous PCL-Gelatin Dressing Containing Red Ginseng Plant Extract for Healing Full-Thickness Wounds in Rats

84

lipid profile in patients with arthritis rheumatoid referred to rheumatology clinic of Rafsanjan city in 2023

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